Gaining Insight Into Pre-mRNA Splicing By The Spliceosome (Seminar Series, Mendel lectures)- REINHARD LÜHRMANN
17:00
Reinhard Lührmann has led pioneering studies to determine the composition, function and architecture of the spliceosome, the mega-Dalton RNP machine that catalyses pre-mRNA splicing. His work has, over several decades, revealed how the main building blocks of the spliceosome, the snRNPs, together with numerous auxiliary factors, assemble dynamically onto a nascent pre-mRNA molecule to generate a catalytically active machine. A major concept that emerged from this work is that the spliceosome's RNP structure undergoes continual remodelling during the splicing cycle, with dramatic exchanges of proteins occurring at multiple intermediate assembly stages of the splicing process. Lührmann’s discoveries in the field of pre‐mRNA splicing have provided foundational knowledge for understanding both splicing regulation, a process that is essential for human cellular function, and the mis-regulation of splicing, which contributes to numerous human diseases.