Research Topics

Naše skupina je zaměřená na základní výzkum v oblasti studia struktury, dynamiky, vzájemných interakcí a biologických funkcí bílkovin. Zvláštní pozornost věnujeme flexibilním bílkovinám, které se nedají popsat jedinou 3D strukturou. Na výzkumu se intenzivně podílejí studenti univerzity od bakalářských až po doktorské programy a rádi uvítáme zájemce o vědu i z řad středoškolských studentů (například v rámci Středoškolské odborné činnosti).

Our group is interested in structure, dynamics, interactions, and function of proteins. Currently, our major focus is proteins containing intrinsically disordered regions. Due to the presence of the intrinsically disordered regions, nuclear magnetic resonance (NMR) plays an important role in detailed characterization of the studied proteins. In addition to conventional NMR methods, we have developed approaches allowing us to study large disordered proteins with atomic-resolution. We combine NMR spectroscopy with cryo-electron microscopy to describe interactions of the investigated proteins and their complexes at conditions close to their natural environment. Currently, we study mostly two types of biological systems: (1) proteins regulating bacterial transcription and (2) microtubule-associated proteins of brain neurons and their interacting partners.

Team Members

• Researchers: Jozef Hritz, Séverine Jansen, Petr Padrta, Pavel Kadeřávek  

Members of the laboratory also participate in the Lukas Zidek research group at CEITEC MU.