SBS: RNDr. Matej Antol, Ph.D. - prezentation

Come and enjoy a great presentatiojn of RNDr. Matej Antol, Ph.D. - prezentation on „AlphaFind: discover structure similarity across the proteome“

The evolution of protein structure databases, from the Protein Data Bank (PDB) in the 1970s to the AlphaFold system in 2021, has led to an unprecedented expansion in known protein structures. Current databases now contain hundreds of millions of predicted structures. This vast increase in data offers immense opportunities for biological research but also presents challenges in terms of accessibility and practical use. To bridge the gap between the expansive AlphaFold Database (containing 214 million proteins and occupying 21 TB of storage) and structural biology researchers, we developed AlphaFind. This web-based similarity search system allows for rapid detection of similar proteins. In contrast to traditional search methods based on metadata, AlphaFind employs a purely data-centric search strategy, extracting semantic information directly from the protein features themselves.